| Vascular thrombosis |
|
Anticardiolipin antibodies |
| |
One or more clinical episodes of arterial, venous,
or small-vessel thrombosis, occurring within any tissue or organ |
|
|
Anticardiolipin IgG and / or
IgM antibodies present at moderate or high levels on two or
more occasions at least 12 weeks apart |
| Complications of pregnancy |
|
Lupus anticoagulant antibodies |
| |
(a) One or more unexplained deaths of
morphologically normal foetuses at or after the 10th week of
gestation; OR
(b) One or more premature births of morphologically normal neonates
at or before the 34th week of gestation; OR
(c) Three or more unexplained consecutive spontaneous abortions
before the 10th week of gestation |
|
|
Lupus anticoagulant antibodies
detected on two or more occasions at least 12 weeks apart,
according to the guidelines of the International Society on
Thrombosis and Hemostasis |
| |
|
Anti-b2 glycoprotein-I antibodies
|
| |
|
|
Anti-b2 glycoprotein-I IgG and
/ or IgM present at high titers as detected by a standardized
ELISA on two or more occasions at least 12 weeks apart |
| *A diagnosis of definite antiphospholipid
syndrome requires the presence of at least one of the clinical
criteria and at least one of the laboratory criteria. Classification
of antiphospholipid syndrome should be avoided if less than
12 weeks or more than 5 years separate the positive antiphospholipid
tests and the clinical manifestations. |