Plate III
COMBINATION THERAPY FOR MANIA
20%-25% more patients respond
  Level of evidence  
Lithium / valproate + quetiapine 1 1st line
Lithium / valproate + risperidone 1 1st line
     
Lithium / valproate + olanzapine 2 1st line
     
Lithium + valproate 3 2nd line
Lithium / valproate + haloperidol 1 3rd line
Lithium + carbamazepine 2 3rd line
Valproate + carbamazepine 3 3rd line
Carbamazepine + risperidone 3 X